Evidence map›Paper›PMID 42383988›Full record

ArticleAntimicrobial agents and chemotherapy2026

Indole-based hybrids target both asexual parasites and gametocytes of

Abhinab Mohanty, Myna Nakabashi, Barbara K M Dias, Pedro Maiolini, José Antonio Campos Delgado, Karina de Souza Quaglio, Márcio Weber Paixão, Celia R S Garcia

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abhinab MohantyDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0009-0000-6524-8005
Myna NakabashiDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.
Barbara K M DiasDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.
Pedro MaioliniDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.
José Antonio Campos DelgadoLaboratory for Sustainable Organic Synthesis and Catalysis, Department of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, São Paulo, Brazil.ORCID 0000-0002-5994-7384
Karina de Souza QuaglioLaboratory for Sustainable Organic Synthesis and Catalysis, Department of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, São Paulo, Brazil.ORCID 0000-0002-4415-949X
Márcio Weber PaixãoLaboratory for Sustainable Organic Synthesis and Catalysis, Department of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, São Paulo, Brazil.
Celia R S GarciaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0003-2825-1701

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304638/2023-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.896791/2023-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/15522-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/07656-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/09115-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/04088-7
6 · The paper itself

Abstract

Malaria remains a persistent global health challenge, and emerging resistance to artemisinin-based therapy threatens disease control. Here, we report the evaluation of scaffolds selected from three classes of indole hybrids. A library of 24 synthetically designed indoles was screened

Indexed as

AntimalarialsEthanolaminesFluorenesIndolesPlasmodium falciparumDrug SynergismHEK293 CellsHumansLumefantrineParasitic Sensitivity TestsAntimalarialsEthanolaminesFluorenesIndolesLumefantrineantimalarialscombination therapygametocyteindole derivativesPlasmodium falciparum

Identifiers

PMID42383988
PMCPMC13436391

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.