Evidence map›Paper›PMID 42384284›Full record

ArticleMedical oncology (Northwood, London, England)2026

DC-intrinsic SHP1 restrains central memory CD8⁺ T cell formation via the TCF-1/Wnt/β-Catenin axis.

Bing Li, Huilin Lu, Jiayi Huang, Yusheng Liang, Weize Yu, Shunhong Wu, Ting Lei, Xiaoming Tan, Yuan Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bing Li *School of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China.
Huilin Lu *School of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China.
Jiayi Huang *School of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China.
Yusheng LiangSchool of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China.
Weize YuCollege of Pharmacy, Dali University, No. 22, Wanhua Road, Xiaguan Town, Dali, 671000, China.
Shunhong WuSchool of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China.
Ting LeiCollege of Pharmacy, Dali University, No. 22, Wanhua Road, Xiaguan Town, Dali, 671000, China. leiting@dali.edu.cn.
Xiaoming TanQingyuan Maternal and Child Healthcare Hospital, No. 22, Shuguang 2Nd Road, Qingcheng District, Qingyuan, 511500, China. txmwmh@163.com.
Yuan ZhangSchool of Pharmaceutical Sciences, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, China. zhangyuanlazy@gzhmu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515220102National Natural Science Foundation of China 82304532
6 · The paper itself

Abstract

The tumor microenvironment (TME) limits durable antitumor immunity by impairing CD8

Indexed as

beta CateninCD8-Positive T-LymphocytesDendritic CellsProtein Tyrosine Phosphatase, Non-Receptor Type 6T Cell Transcription Factor 1Wnt Signaling PathwayAnimalsHepatocyte Nuclear Factor 1-alphaImmunologic MemoryMiceMice, Inbred C57BLMice, Knockoutbeta CateninCTNNB1 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseT Cell Transcription Factor 1Dendritic cellsSHP-1TCF-1TCMWnt/β-catenin

Identifiers

PMID42384284

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.