Evidence map›Paper›PMID 42384787›Full record

ArticleScience advances2026

Turbocharging synaptic transmission: 12 SNAREpins are required for rapid release of reconstituted synaptic vesicles.

Manindra Bera, Atrouli Chatterjee, Amit Koikkarah Aji, Aniruddha Panda, R Venkat K Sundaram, Jeff Coleman, Reza Maroofian, Vincenzo Salpietro, Abhijith Radhakrishnan, Sudhanshu Gautam and 7 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Manindra BeraDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-9297-8126
Atrouli ChatterjeeDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
Amit Koikkarah AjiDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-1689-1015
Aniruddha PandaDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-9447-9547
R Venkat K SundaramDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
Jeff ColemanDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-0110-9289
Reza MaroofianDepartment of Neuromuscular Diseases, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.ORCID 0000-0001-6763-1542
Vincenzo SalpietroDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Abhijith RadhakrishnanDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-8107-3487
Sudhanshu GautamDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
Kirill GrushinDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
Matthieu CaruelMSME, UMR 8208, CNRS, Univ Paris Est Creteil, Univ Gustave Eiffel, F-94010 Créteil, France.ORCID 0000-0002-6591-2727
Henry HouldenDepartment of Neuromuscular Diseases, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.ORCID 0000-0002-2866-7777
Kallol GuptaDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-3557-3242
Sathish RamakrishnanNanobiology Institute, Yale University, West Haven, CT 06516, USA.ORCID 0000-0002-7844-2234
Frederic PincetDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-4243-2157
James E RothmanDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-4822-4161

Funding

Decoding the Molecular Choreography of Diverse Vesicle Release MechanismsR35GM160124 · NIGMS · YALE UNIVERSITY · PI RAMAKRISHNAN, SATHISH K · 2025 to 2025
$2.3M
NIGMS NIH HHS R35 GM160124
6 · The paper itself

Abstract

Synaptic transmission occurs synchronously with real-world events, far faster than vesicle fusion for hormone release or membrane biogenesis, all mediated by soluble

Indexed as

SNARE ProteinsSynaptic TransmissionSynaptic VesiclesAnimalsHumansMiceSynaptophysinVesicle-Associated Membrane Protein 2SNARE ProteinsSynaptophysinVesicle-Associated Membrane Protein 2

Identifiers

PMID42384787
PMCPMC13322239

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.