ReviewScience advances2026
Illuminating aging with multimodal optical metabolic imaging.
Review in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
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Abstract
Aging is intimately entangled with the reprogramming of metabolic pathways that coordinate energy production, biosynthesis, and molecular turnover. However, visualizing and understanding these metabolic underpinnings within their spatial and temporal contexts remains a major challenge. Metabolic imaging has emerged as a transformative approach that enables spatially resolved visualization of metabolic dynamics both at the molecular or cellular and organismal levels. In this review, we summarize recent advances and applications of metabolic imaging in probing aging biology, with particular emphasis on multimodal nonlinear optical imaging techniques and their applications across diverse aging models. Optical metabolic imaging provides unique insights into the mechanisms of aging by capturing metabolic alterations that span from organelle-level interactions to tissue-scale remodeling. Optical metabolic imaging enables the label-free detection of early metabolic shifts in vivo, representing an emerging frontier in aging research. Looking ahead, optical metabolic imaging holds great promise as a practical and powerful tool for clinical translation, advancing precision medicine and enhancing the diagnosis, monitoring, and evaluation of aging processes to promote human health span and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.