ReviewInternational journal of cancer2026
Bispecific Antibody-Based Combination Therapies for B-Cell Lymphomas: Current Evidence and Future Perspectives.
Review in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
The introduction of rituximab revolutionized the treatment landscape of B-cell lymphomas, establishing immunotherapy as a cornerstone of therapeutic strategies. Bispecific antibodies (BsAbs) have demonstrated remarkable efficacy in hematologic malignancies, including B-cell lymphomas, and select solid tumors. However, their single-agent activity remains limited by primary or acquired resistance. To overcome these challenges, current research has shifted toward exploring combination strategies integrating BsAbs with chemotherapy, targeted therapies, and other immunotherapies. This review comprehensively summarizes recent advances in BsAb-based combination therapies for B-cell lymphomas, with a focus on ongoing clinical trials and their preliminary outcomes. Furthermore, we discuss the mechanistic rationale, potential synergies, and challenges of these approaches, aiming to provide insights for optimizing future treatment paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.