Evidence map›Paper›PMID 42386483›Full record

ArticleJournal of cardiothoracic and vascular anesthesia2026

An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An Exploratory Study.

Sirintip Swangwong, Kelsey Sullivan, Erik Malm, Samuel Kim, David Faraoni, Kirsten Odegard, Koichi Yuki

Abstract read
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In one paragraph

Article in Journal of cardiothoracic and vascular anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sirintip SwangwongDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA; Department of Anaesthesia, Harvard Medical School, Boston, MA; Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kelsey SullivanDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.
Erik MalmDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.
Samuel KimDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.
David FaraoniDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA; Department of Anaesthesia, Harvard Medical School, Boston, MA.
Kirsten OdegardDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA; Department of Anaesthesia, Harvard Medical School, Boston, MA.
Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA; Department of Anaesthesia, Harvard Medical School, Boston, MA; Department of Immunology, Harvard Medical School, Broad Institute of MIT and Harvard, Cambridge, MA. Electronic address: koichi.yuki@childrens.harvard.edu.

Funding

The role of damage-associated molecular patterns in perioperative morbidities and mortalities of pediatric congenital heart diseasesR21HD109119 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2022 to 2023
$487k
NICHD NIH HHS R21 HD109119
6 · The paper itself

Abstract

objectivesInadequate heparin response is frequently observed in neonates and young infants. While low antithrombin level is considered to be the primary cause, the existing literature suggests that it is not necessarily responsible. However, granular coagulation factor profiling data are rather limited.

designProspective, single-center study.

settingTertiary academic hospital in the United States.

participantsTotal of 30 neonates and infants who underwent cardiac surgery with cardiopulmonary bypass between May 31, 2022, and February 22, 2023.

interventionsNone. MEASUREMENTS AND MAIN

resultsComparison between the heparin response group and the inadequate heparin response group demonstrated that antithrombin levels were comparable. However, levels of another thrombin inhibitor, α

conclusionsLower α

Indexed as

AnticoagulantsAntithrombinsCardiac Surgical ProceduresHeparinalpha-MacroglobulinsFemaleHumansInfantInfant, NewbornMaleProspective StudiesProtein Salpha-MacroglobulinsAnticoagulantsAntithrombinsHeparinProtein Santithrombinheparin responseprotein Sα(2)-macroglobulin

Identifiers

PMID42386483
PMCPMC13323956

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.