Evidence map›Paper›PMID 42386902›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Assessing the real-world effects of prophylactic hydrocortisone in the Canadian Neonatal Network: A cohort study.

Marisa de Souza, Marc Beltempo, Bernard Thébaud, Yi-Chen Su, Brooke Read, Amit Mukerji, Brigitte Lemyre, Canadian Neonatal Network

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marisa de SouzaUniversity of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0009-0003-7986-7669
Marc BeltempoMcGill University Health Centre, Montreal, QC, Canada.
Bernard ThébaudUniversity of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-1844-7145
Yi-Chen SuDepartment of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.ORCID http://orcid.org/0009-0006-8954-0274
Brooke ReadLondon Health Sciences Centre, London, ON, Canada.
Amit MukerjiMcMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0003-2609-9240
Brigitte LemyreUniversity of Ottawa, Ottawa, ON, Canada. blemyre@toh.ca.ORCID http://orcid.org/0000-0003-2743-0417
Canadian Neonatal Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effects of prophylactic hydrocortisone (pHCT) on the odds of death or moderate to severe bronchopulmonary dysplasia (BPD) in preterm neonates. STUDY

designMulti-center retrospective cohort study of infants born <28 weeks in the Canadian Neonatal Network 2019-2023 who received pHCT with 1:1 propensity score-matched controls. Hierarchical composite endpoints were explored using win odds analyses.

resultsThere were 361 infants per group with balanced baseline characteristics. There were no differences in the odds of death or moderate to severe BPD (pHCT 259/361 [71.8%] vs. control 264/361 [73.1%], OR 0.92, 95% CI [0.68, 1.24]). Win odds (95% CI) were not different: 1.02 (0.85, 1.28). There was lower use of systemic postnatal steroids and treatment of patent ductus arteriosus in the pHCT group; no significant differences in other safety outcomes were observed.

conclusionspHCT was not associated with reductions in mortality nor moderate to severe BPD.

Identifiers

PMID42386902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.