Evidence map›Paper›PMID 42386943›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Association between hypertension phenotypes and aortic valve peak velocity: a potential tool for identifying white-coat hypertension.

Dimitrios Konstantinidis, Konstantinos G Kyriakoulis, Georgios Papadopoulos, Angeliki Vakka, Konstantia Papadomarkaki, Panagiotis Iliakis, Kyriakos Dimitriadis, Konstantinos Tsioufis

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Dimitrios Konstantinidis *First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos G Kyriakoulis *First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Georgios PapadopoulosFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Angeliki VakkaFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantia PapadomarkakiFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis IliakisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Kyriakos DimitriadisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos TsioufisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece. ktsioufis@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension phenotypes reflect the agreement or disagreement between office and out-of-office blood pressure (BP) measurements and are challenging to distinguish during a single office visit. Increased sympathetic nervous system (SNS) activity is implicated in their pathophysiology. Aortic valve peak velocity, an echocardiographic parameter associated with SNS hyperactivity and high cardiac output states, may help differentiate hypertension phenotypes. This study examined the association between hypertension phenotypes and aortic valve peak velocity. Cross-sectional analysis of consecutive patients evaluated at a reference Hypertension Unit who underwent office (OBP), ambulatory BP (ABP) monitoring, and echocardiography. A total of 384 participants were included (mean age 58 years; 55% male; 60% treated systolic/diastolic OBP 136/84 mmHg, ABP 126/77 mmHg, aortic valve peak velocity 1.31 m/s, 34% normotension/controlled hypertension, 18% white-coat hypertension/white-coat uncontrolled hypertension (WCH/WCUH), 16% masked hypertension/masked uncontrolled hypertension, 32% sustained hypertension/uncontrolled hypertension]. Aortic valve peak velocity was significantly higher in the WCH/WCUH group (1.40 ± 0.26 m/s) compared with all other phenotypes (P < 0.01). This finding was consistent in analyses restricted to untreated patients and to those with a short ABP-echocardiography time interval, and remained significant in multivariable linear regression models. Among participants with office hypertension, a cut-off value of 1.32 m/s demonstrated moderate diagnostic accuracy for identifying WCH/WCUH (sensitivity 62%, specificity 66%). Aortic valve peak velocity is significantly elevated in WCH/WCUH and may serve as a supportive clinical tool to help identify or exclude this phenotype in patients presenting with office hypertension, particularly in untreated individuals undergoing baseline echocardiography.

Indexed as

Aortic valve peak velocityEchocardiographyHypertension phenotypesWhite-coat hypertensionWhite-coat uncontrolled hypertension

Identifiers

PMID42386943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.