ArticleAlimentary pharmacology & therapeutics2026
A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection.
Article in Alimentary pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection.Alimentary pharmacology & therapeutics · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
aimsThe immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite high infection rates. This study investigated the differences in immune cell phenotypes in four distinct clinical phases of disease in an Ethiopian cohort.
methodsTwo hundred eighty-seven patients with untreated HBV infection, and no human immunodeficiency virus and hepatitis C virus infection, were included at Adama Hospital, Ethiopia. Patients were categorized based on clinical parameters into the following groups: low-replicative infection, "greyzone", active hepatitis, and cirrhosis. Whole blood samples were cryopreserved using Cytodelics Whole Blood Cell Stabilizer and analysed using two high-dimensional flow cytometry panels to define immune cell phenotypes.
resultsPatients with cirrhosis displayed a distinct immunophenotype compared to other phases of chronic HBV infection with an increase in monocytes and a reduction in all lymphocytes alongside a shift from a mature to a naïve phenotype in NK cells, CD4
conclusionsHBV-associated cirrhosis in Ethiopia displayed a unique immunophenotype, in which the frequency of CD38
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