Evidence map›Paper›PMID 42387502›Full record

ArticleRespiratory research2026

The autonomic nervous system-lung interface in experimental BPD: NPY modulates immune response, alveolar growth and vascular muscularizationin neonatal mice exposed to oxidative stress.

Clemens O Nies, Caroline Zeitouny, Celien Kuiper-Makris, Dharmesh Hirani, Jaco Selle, Christoph Bartz, Christina Vohlen, Jule Schmidt, Ruth Janoschek, Ivana Mižik and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Clemens O Nies *Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Caroline Zeitouny *Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Celien Kuiper-MakrisFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Dharmesh HiraniFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Jaco SelleFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Christoph BartzFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Christina VohlenFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Jule SchmidtFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Ruth JanoschekFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Ivana MižikDepartment of Translational Pulmonology and Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research (DZL), University Hospital Heidelberg, Heidelberg, Germany.
Margarete OdenthalFaculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany.
Silke V Koningsbruggen-RietschelFaculty of Medicine and University Hospital Cologne, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Herbert HerzogFaculty of Medicine, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Werner SeegerInstitute for Lung Health (ILH), Cardiopulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany.
Julian U G WagnerInstitute of Cardiovascular Regeneration, Centre for Molecular Medicine, Cardiopulmonary Institute (CPI), and German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Goethe University Frankfurt, Frankfurt a.M., Germany.
Jörg DötschFaculty of Medicine and University Hospital Cologne, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany.
Julian KoenigFaculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany.
Miguel A Alejandre AlcazarFaculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, University of Cologne, Cologne, Germany. miguel.alejandre-alcazar@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygen supplementation triggers inflammation and disrupts alveolar and microvascular growth in preterm infants, often leading to bronchopulmonary dysplasia (BPD). The autonomic nervous system (ANS) is critical in lung tissue homeostasis and repair. The sympathetic co-neurotransmitter neuropeptide Y (NPY) emerges as a central regulator of the ANS-organ interface with immune-modulatory function. Here, we studied sympathetic nervous system (SNS) signaling and the contribution of NPY to a hyperoxia-based model of BPD. To this end, neonatal wild-type (WT) and NPY knockout mice (NPY

Indexed as

Autonomic Nervous SystemBronchopulmonary DysplasiaLungNeuropeptide YOxidative StressPulmonary AlveoliAnimalsAnimals, NewbornDisease Models, AnimalHyperoxiaMaleMiceMice, Inbred C57BLMice, KnockoutNeuropeptide YAlveolar type 2 cells (AT2)Autonomic nervous system (ANS)Bronchopulmonary dysplasia (BPD)HyperoxiaNeuropeptide Y (NPY)Sympathetic nervous system (SNS)

Identifiers

PMID42387502
PMCPMC13366976

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.