Impact of Respiratory Effort Parameters on Clinical Outcomes in Respiratory Failure Patients (Effort-I): A Prospective Observational Study.

Phruet Soipetkasem, Touchapong Taksinwarajarn, Detajin Junhasavasdikul, Yuda Sutherasan, Pongdhep Theerawit

Registry-linked trialAbstract read

In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06433076 (The Association Between Respiratory Effort Parameters During the First 48 Hours With Clinical Outcomes in Mechanically Ventilated Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06433076 completednot on this map

The Association Between Respiratory Effort Parameters During the First 48 Hours With Clinical Outcomes in Mechanically Ventilated Patients: A Prospective Observational Study.

TypeobservationalSponsorRamathibodi HospitalRan2022 to 2024Enrolled163ConditionsRespiratory Effort, Respiratory Distress Syndrome, Lung Mechanics

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Phruet SoipetkasemDivision of Critical Care Medicine Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Touchapong TaksinwarajarnDivision of Pulmonary and Pulmonary Critical Care Medicine Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Detajin JunhasavasdikulDivision of Pulmonary and Pulmonary Critical Care Medicine Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Yuda SutherasanDivision of Pulmonary and Pulmonary Critical Care Medicine Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Pongdhep TheerawitDivision of Critical Care Medicine Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Excessive or insufficient respiratory drive and inspiratory effort during mechanical ventilation may worsen outcomes through patient self-inflicted lung injury or diaphragm disuse. We evaluated whether bedside measures of respiratory drive and effort during the first 48 h of ventilation were associated with outcomes in critically ill adults with acute respiratory failure. Methods: In this single-center, prospective, observational study, adults aged 18-75 years with acute respiratory failure requiring invasive mechanical ventilation and a PaO Results: A total of 206 patients were included. Patients within prespecified preferred ranges (P Conclusions: Early respiratory drive and inspiratory effort within preferred physiological ranges were associated with more VFDs and lower mortality. Calculated ΔP Trial Registration: NCT06433076. Registered 29 May 2024, retrospectively registered.

Indexed as

Mechanical ventilationP0.1 Transpulmonary driving pressureRespiratory effortVentilator-free days

Identifiers

PMID42388558

DOI10.1016/j.aicoj.2026.100103

PMCPMC13321231

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

NCT06433076ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.