ArticleFrontiers in neuroscience2026
Impact of C-reactive protein-triglyceride-glucose and systemic immune-inflammation indices on obstructive sleep apnea in older adults with depression.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Both the C-reactive protein (CRP)-triglyceride-glucose index (CTI) and the systemic immune-inflammation index (SII) are easily accessible, cost-effective, and rapid indices derived from biochemical examinations. The study aimed to identify the roles of the CTI and SII in older adults with comorbid obstructive sleep apnea (OSA) and depression. Methods: The study included 52 older patients with depression coexisting with OSA and 108 patients with depression but without OSA. The CTI was calculated using the following equation: 0.412 × Ln (CRP) (mg/dL) + Ln [triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The SII was calculated using the formula: platelet × neutrophil/lymphocyte. Results: A greater proportion of men and a higher mean body mass index were found in older adults with comorbid OSA and depression compared to those with depression only ( Conclusion: The study demonstrated that higher CTI and SII values may be associated with comorbid OSA and depression in older adults.
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