Trial reportFrontiers in neurology
Effect and mechanism of repetitive transcranial magnetic stimulation of angular gyrus on patients with consciousness disorder.
Trial report in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine whether high-frequency rTMS of the left angular gyrus improves behavioral signs of consciousness in prolonged disorders of consciousness (pDoC) and to identify network mechanisms and predictors of response. Methods: In a randomized, double-blind, sham-controlled crossover trial, patients with pDoC received 3 weeks of 20-Hz rTMS over the left angular gyrus and 3 weeks of sham stimulation in counterbalanced order, separated by a 1-week washout. Consciousness was evaluated using the Coma Recovery Scale-Revised (CRS-R). Resting-state fMRI was acquired at baseline and after each period to quantify network-level changes. Explainable machine-learning models related stimulation-induced network changes and baseline features to behavioral improvement. Results: Forty patients completed the trial. Behavioral improvement occurred more frequently during active than sham stimulation ( Conclusion: Left angular gyrus rTMS improved consciousness-related behaviors in a subset of pDoC patients, potentially mediated by DMN-SCN network reconfiguration; patients with stronger baseline within-DMN connectivity were more likely to benefit. Clinical trial registration: https://www.chictr.org.cn/index.html, identifier ChiCTR2300069980.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.