Evidence map›Paper›PMID 42388713›Full record

ArticleFrontiers in neurology2026

Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS.

Yidi Zhu, Luoyu Wang, Liqing Zhang, Xue Tang, Maoling Liu, Qingqing Wen, Darong Zhu, Han Zhang, Xiufang Xu, Zhongxiang Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yidi Zhu *School of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
Luoyu Wang *School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Liqing ZhangDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Xue TangSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
Maoling LiuSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
Qingqing WenMR Research, GE Healthcare, Beijing, China.
Darong ZhuDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Han ZhangSchool of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Xiufang XuSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
Zhongxiang DingDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Middle cerebral artery stenosis (MCA-S) impairs cerebral perfusion and vascular pulsatility, potentially disrupting cerebrospinal fluid dynamics. We evaluated perivascular diffusivity in MCA-S using diffusion tensor image analysis along the perivascular space (DTI-ALPS) index and the redirected ALPS (ro-ALPS) index, and assessed their clinical correlations. Methods: Thirty-seven patients with MCA-S and 41 matched healthy controls (HCs) underwent MRI and cognitive function testing. We compared the DTI-ALPS index and ro-ALPS indices between the two groups and performed correlation analyses with cognitive scores and clinical indicators, including high-density lipoprotein, homocysteine, and choroid plexus (CP) volume. Results: The results showed that both DTI-ALPS index and ro-ALPS index were significantly lower in the MCA-S group than in the HC group (both Conclusion: These findings suggest that perivascular clearance is impaired in patients with MCA-S, as reflected by lower ALPS indices. These ALPS indices, as imaging biomarkers, show significant associations with CP volume, suggesting their potential utility in monitoring disease progression.

Indexed as

choroid plexuscognitive dysfunctiondiffusion tensor imaging along the perivascular space indexglymphatic systemmiddle cerebral artery stenosis

Identifiers

PMID42388713
PMCPMC13318568

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.