Observational studyFrontiers in endocrinology2026
Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study.
Observational study in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05404464 (CITIC Xiangya Assisted Reproduction Data Repository), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CITIC Xiangya Assisted Reproduction Data Repository: a Real Medical Environment Based Research Database
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Insulin resistance has been linked to adverse reproductive and pregnancy outcomes. The triglyceride glucose-body mass index (TyG-BMI) serves as a simple and cost-effective surrogate marker of insulin resistance. This study aimed to investigate the association between maternal TyG-BMI and cumulative live birth as well as pregnancy outcomes in women undergoing assisted reproductive technology. Methods: This retrospective cohort study included 53,393 women undergoing assisted reproductive technology at the Reproductive and Genetic Hospital of CITIC-Xiangya, China, between January 1, 2017, and March 31, 2023. Associations between baseline TyG-BMI and assisted pregnancy outcomes were estimated using modified Poisson regression and restricted cubic splines. Results: A significant linear inverse association was observed between TyG-BMI and cumulative live birth rate ( Conclusions: Higher maternal TyG-BMI is associated with reduced cumulative live birth rates and higher risks of adverse pregnancy outcomes including miscarriage, preterm birth, and macrosomia following assisted reproductive technology. TyG-BMI may be a potential and cost-effective marker associated with adverse reproductive outcomes in women undergoing fertility treatment. Clinical Trial Registration: https://www.clinicaltrials.gov, identifier NCT05404464.
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