ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
FTLD-TDP versus LATE-NC: Experience of a Brain Bank specializing in FTLD-TDP.
D Luke Fischer, Salvatore Spina, Bruce L Miller, William W Seeley, Lea T Grinberg
Abstract read
In one paragraphArticle in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
D Luke FischerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California San Francisco California USA.ORCID https://orcid.org/0000-0002-5245-3832 Salvatore SpinaEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California San Francisco California USA.
Bruce L MillerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California San Francisco California USA.
William W SeeleyEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California San Francisco California USA.
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MARIA LUISA GORNO TEMPINI · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MNINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6MNeuropathological changes underlying clinical heterogeneity in Alzheimer diseaseK24AG053435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRINBERG, LEA TENENHOLZ · 2016 to 2025
$1.8MNIA NIH HHS K24 AG053435NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NINDS NIH HHS U54 NS092089NINDS NIH HHS UE5 NS070680
6 · The paper itselfAbstract
introductionSimilarities between frontotemporal lobar degeneration with transactive response DNA-binding protein of 43 kDa (TDP-43) (FTLD-TDP) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) raise questions about whether they represent distinct entities or a single disease spectrum. The literature mostly examined series with disproportionate numbers of LATE-NC over FTLD-TDP.
methodsLeveraging a clinicopathological collection of FTLD-TDP (
resultsFTLD-TDP type A cases were younger at onset and death, had shorter disease duration, and frequent genetic causes ( DISCUSSION: These overall findings support distinct diagnostic entities for FTLD-TDP and LATE-NC.
Indexed as
Alzheimer's diseaseautopsyDNA‐binding proteinsfrontotemporal lobar degenerationlimbic‐predominant age‐related TDP‐43 encephalopathy
Identifiers
PMID42388895
PMCPMC13319421
What Socratic holds
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