Evidence map›Paper›PMID 42389017›Full record

ArticleBioactive materials2026

Mechanical loading primes MSC-derived exosomes to promote cartilage repair.

Zeng Lin, Chao Jia, Hongwei Lu, Lei Zhou, Jie Guo, Borui Jin, Jinjin Wang, Abudula Aji, Peng Luo, Ling Cai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zeng LinDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200040, PR China.
Chao JiaDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Hongwei LuDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Lei ZhouDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Jie GuoDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Borui JinDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Jinjin WangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Abudula AjiDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Peng LuoDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China.
Ling CaiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Libo JiangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Zhenwu WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Xing WuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200040, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage defects remain a major clinical challenge due to the limited efficacy of current therapies and the intrinsically low regenerative capacity of chondrocytes. Mechanical loading has emerged as a promising strategy to enhance stem cell-based cartilage repair; however, the underlying molecular mechanisms remain poorly understood. Here, we show that cyclic tensile strain primes mesenchymal stem cells (MSCs) to secrete exosomes enriched in microRNA-330-3p (

Identifiers

PMID42389017
PMCPMC13320261

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.