Evidence map›Paper›PMID 42389021›Full record

ArticleBioactive materials2026

Immunity-and-matrix-regulatory cells promote hyaline-like cartilage repair in osteoarthritis.

Yiqi Su, Zihao He, Kai Wang, Tingting Gao, Jiao Jiao Li, Qianqian Chen, Long Chen, Shasha Liu, Fanhao Ye, Jingzhou Wang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yiqi SuArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Zihao HeArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Kai WangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Tingting GaoState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Jiao Jiao LiSchool of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Qianqian ChenThird Clinical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Long ChenArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Shasha LiuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Fanhao YeArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Jingzhou WangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Shichun XuArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Du WangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Zhen YangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Zijin ZhouArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Caiyi WeiArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Jun WuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Jianhao LinArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Hui LiArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Dan XingArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Articular cartilage repair in osteoarthritis (OA) remains a major clinical challenge. Although approaches using mesenchymal stem cells (MSCs) have demonstrated partial efficacy in OA, the regenerated tissue is often unable to form stable hyaline-like cartilage phenotype. Here, we introduce immunity-and-matrix-regulatory cells (IMRCs), derived from human embryonic stem cells (ESCs), as an alternative cell source for OA therapy. Using a multiple-level platform including 2D chondrocytes, 3D OA cartilage organoids (OCOs), rabbit cartilage explants, and a rat OA model, we demonstrate that IMRCs significantly enhance hyaline-like matrix formation while suppressing inflammation, angiogenesis, and fibrotic remodeling. Mechanistically, IMRC-mediated cartilage repair is partially associated with MMP1-dependent matrix remodeling. This study establishes a translational evaluation strategy for IMRCs and points to their potential as an alternative cell source for inducing cartilage repair in OA. Notably, the OCOs established in this study provide a pathologically relevant

Indexed as

Cartilage fibrosisCartilage organoidsCartilage regenerationImmunity-and-matrix-regulatory cellsOsteoarthritis

Identifiers

PMID42389021
PMCPMC13320253

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.