ArticleMedComm2026
Multiomics Identification and Validation of an Integrin-Extracellular Matrix Network Driving Respiratory Syncytial Virus-Induced Lung Injury and Repair.
Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Respiratory syncytial virus (RSV) is a major cause of severe lung injury, particularly in infants. Most previous studies have relied on single-omics or single-model systems, limiting a comprehensive understanding of the dynamic and coordinated host response. To overcome this, we employed an integrated multiomics approach across complementary in vivo (murine) and physiologically relevant ex vivo (human bronchial organoid) models, combining longitudinal transcriptomic and proteomic profiling to systematically delineate the spatiotemporal dynamics of RSV-induced lung injury and repair. Our analysis revealed a stage-specific progression from early inflammatory injury to late repair, in which extracellular matrix (ECM)-receptor interaction and PI3K-Akt signaling play central roles. Moreover, a core set of hub genes including
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