Evidence map›Paper›PMID 42389227›Full record

ArticleInfection and drug resistance2026

Genotype Complexity Modulates Antimalarial Susceptibility in vitro.

Chinedu Ogbonnia Egwu, Olusola Ajibaye, Fatoumata Bojang, Haddijatou Mbye, Vincent Ntui Ntui-Njock, Ndey Fatou Drammeh, Eniyou Cheryll Oriero, Alfred Amambua-Ngwa

Abstract read
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In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chinedu Ogbonnia Egwu *Disease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.ORCID 0000-0003-3408-5471
Olusola Ajibaye *Disease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.ORCID 0000-0002-3888-2366
Fatoumata BojangDisease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.
Haddijatou MbyeDisease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.ORCID 0000-0001-8402-9182
Vincent Ntui Ntui-NjockDisease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.
Ndey Fatou DrammehDisease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.
Eniyou Cheryll OrieroDisease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.
Alfred Amambua-Ngwa *Disease Control and Elimination, Medical Research Council Unit, Banjul, The Gambia.ORCID 0000-0003-4478-3601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Increased tolerance and resistance to antimalarial drugs is one of the major threats responsible for the stagnation in the fight against malaria. The role of Objective: This study investigated the impact of mixed infections of resistant and susceptible strains to antimalarials. Methods: Fifteen Gambian field isolates and two laboratory strains (Dd2 and 3D7) were used for the complexity assays. IC Results: Our findings show that the resistant haplotype in a mixed infection drives the drug response through a significant ( Conclusion: Responses under drug pressure are strongly driven by the resistant haplotypes circulating alongside the wild types of

Indexed as

drug survival assayexposuregenotype complexitymixed infectionsresistancesubtherapeutic

Identifiers

PMID42389227
PMCPMC13321159

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.