ArticleSexual medicine2026
Causal association between statin use and erectile dysfunction: a 2-sample Mendelian randomization study.
Article in Sexual medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: The impact of statins on erectile dysfunction (ED) remains a subject of intense clinical debate. Previous observational studies have yielded inconsistent results and are often limited by confounding factors and reverse causation. Methods: To investigate the causal relationship between statin use and ED risk through a 2-sample Mendelian randomization (MR) analysis of genome-wide association study summary data from the UK Biobank and FinnGen. Genetic variants for general statins and specific types (atorvastatin, simvastatin, and rosuvastatin) were utilized as instrumental variables. The primary effect was estimated using the inverse variance weighted (IVW) method. Sensitivity analyses, including MR-Egger, weighted median, and MR-PRESSO, and leave-one-out analyses, were conducted to ensure the robustness of the findings, alongside the MR Steiger directionality test to validate causal orientation. Results: IVW analysis demonstrated that general statin use is associated with a higher risk of ED (OR = 1.064; 95% CI, 1.011-1.119; Conclusion: Statin use, particularly atorvastatin and simvastatin, causally increases the risk of ED, whereas rosuvastatin appears to have a neutral effect.
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