Evidence map›Paper›PMID 42389262›Full record

ArticleFrontiers in pharmacology2026

2-Pentadecyl-2-oxazoline alleviates anxiety-like behaviour and modulates the microbiota-gut-brain axis in obese mice.

Nicola Opallo, Adriano Lama, Stefania Melini, Lorena Coretti, Federica Comella, Filomena Del Piano, Nicole Pia Navatti, Alessia D'Andrea, Carmen De Caro, Francesca Lembo and 4 more

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In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicola Opallo *Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Adriano Lama *Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Stefania MeliniDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Lorena CorettiDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Federica ComellaDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Filomena Del PianoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Nicole Pia NavattiDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Alessia D'AndreaDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Carmen De CaroDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Francesca LemboDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Maria Carmela FerranteDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Rosaria MeliDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Giuseppina Mattace Raso *Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Claudio Pirozzi *Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A bidirectional relationship between obesity and anxiety disorders has been increasingly associated with neuroinflammation and dysregulation of the gut-brain axis. Here, we investigated the pharmacological effects of the N-palmitoylethanolamine oxazoline derivative 2-pentadecyl-2-oxazoline (C15OXA) in a mouse model of high-fat diet (HFD)-induced obesity, with particular attention to its central and peripheral mechanisms of action. Male C57Bl/6J mice were fed an HFD for 12 weeks and subsequently treated with C15OXA (30 mg·kg

Indexed as

2-Pentadecyl-2-oxazolinebarrier integritycommensal bacteriaelevated plus maze testhigh-fat dietneuroinflammation

Identifiers

PMID42389262
PMCPMC13318990

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.