Evidence map›Paper›PMID 42389270›Full record

ArticleFrontiers in pharmacology2026

Polyphenol-enriched fraction of

Alain Brice Tueche, Michael Hermann Kengne Kamdem, Jordan Lembe Tonga, Edwin Mpoh Mmutlane, Derek Tantoh Ndinteh, Stéphane Zingue, Dieudonné Njamen

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alain Brice TuecheDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Michael Hermann Kengne KamdemDrug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Jordan Lembe TongaDrug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Edwin Mpoh MmutlaneCentre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Derek Tantoh NdintehDrug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Stéphane ZingueCentre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Dieudonné NjamenDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Breast cancer killed 665,684 patients globally in 2022 despite government efforts and conventional therapies. The hydro-ethanolic extract of Acacia seyal, a sub-Saharan African ethnomedicinal plant, showed moderate cytotoxicity, significant anti-migration and in vivo preventive effects against breast cancer cells. The aim of this study was to propose an improved traditional extract and to evaluate its efficacy and potential mechanism of action. Methods: To achieve this, A. seyal hydro-ethanolic extract (ASHE) was fractionated in polyphenol-enriched (ASpo), polysaccharides (ASsu) and residue (ASre) fractions. Fractions along with the crude extract were tested for their ability to inhibit cell growth (MTT) and proliferation (CCK-8). The promising fraction (ASpo) was further investigated on clone formation, caspase-3, wound healing, chemotaxis and cell adhesion to understand its underlying mechanisms of action. Moreover, ASpo at 18.75 and 37.5 mg/kg, Results: Among the 3 fractions, ASpo compared to control, inhibited ( Conclusion: Overall, ASpo mainly contributed to anti-breast cancer activities of total crude extract and involved immunomodulatory effects to consider with optimized bioactivity to further investigate it as a promising natural and inexpensive alternative to costly and efficient current immunotherapy.

Indexed as

anti-oxidantDMBA carcinogenIFN-γ cytokinemammary tumormetastasismonocytespolyphenolic extract

Identifiers

PMID42389270
PMCPMC13318909

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.