ReviewFrontiers in pharmacology2026
Comparing the effects of propofol and sevoflurane anesthesia on cognitive dysfunction in elderly patients after abdominal surgery: a systematic review and meta-analysis of randomised controlled trials.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To conduct a systematic review and comparison of the effects of propofol and sevoflurane anesthesia on cognitive dysfunction in elderly patients following abdominal surgery. Methods: Comparative studies published in PubMed, Web of Science, EBSCOhost, Cochrane Library, EMBASE, and Medline databases as of 08 Jun 2025 were searched. The final extracted data was analyzed using Review Manager 5.4. Results: The 7 randomized controlled studies included a total of 802 patients who had undergone abdominal surgery, of whom 402 were anesthetized with propofol and 400 were anesthetized with sevoflurane. The outcomes of the meta-analysis showed that there were no statistically significant differences in operating time, anesthesia time, incidence of hypotension, the incidence of postoperative cognitive dysfunction (all P > 0.05), between the propofol and sevoflurane groups. Moreover, there was no significant difference in the severity of cognitive dysfunction between the two groups of patients on the 1st, 3rd, and 7th day after surgery (all P > 0.05). Conclusion: The meta-analysis results showed that there was no significant difference in the severity of cognitive dysfunction between the he propofol and sevoflurane groups of patients on the 1st, 3rd, and 7th day after surgery. This conclusion still does not prove that either one is more suitable for anesthesia in elderly patients, and more samples and clinical studies are needed to confirm. Trial Registration: PROSPERO registration number is: CRD42022324055.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.