Vestibular disorders and monoamine neurotransmitters: Current evidence.

Yujie Liu, Linglin Zhou, Xingxing Chen, E Tian, Yisheng Lu, Peixia Wu, Sulin Zhang, Jun Wang

Abstract readReview

In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yujie LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Linglin ZhouDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Xingxing ChenSchool of Nursing, Jiangxi University of Chinese Medicine, Nanchang, China.

E TianDepartment of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yisheng LuDepartment of Physiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China.

Peixia WuENT Institute and Otorhinolaryngology Department of Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.

Sulin ZhangDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Jun WangDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vestibular system, a crucial sensorimotor apparatus for balance and spatial orientation, is regulated by neurotransmitters. Despite its essential function, the intricacies of neurotransmission within this system, particularly regarding monoamine neurotransmitters, remain not fully explained. A variety of vestibular disorders and therapeutic interventions are associated with balance regulation, underscoring the significance of understanding the neurotransmission in the vestibular system. This comprehensive review offers an overall insight into the role of monoamine neurotransmitters, including serotonin (5-HT), histamine, dopamine, and norepinephrine (NE), in the vestibular compensation following peripheral vestibular dysfunction. By examining the existing literature and integrating recent findings, monoamine neurotransmitters are closely associated with vestibular disorders, and their modulators have been used in the treatment of such conditions. Based on the vestibular dysfunction, we highlight the expression and functional significance of these neurotransmitters in the early vestibular compensation. Future research will further explore the role of neurotransmitters and their receptors in vestibular compensation, providing new ideas for the development of more effective treatment strategies.

Indexed as

biological scienceshealth sciencesmedical specialtymedicinenatural sciencesneuroscienceotorhinolaryngology

Identifiers

PMID42389603

DOI10.1016/j.isci.2026.116401

PMCPMC13319937

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.