Evidence map›Paper›PMID 42389758›Full record

ArticleArchives of internal medicine research2026

Limitations of Current Therapies and Barriers in Alzheimer's Disease.

Ayeshah Hussain, Iffat Alam, Devendra K Agrawal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of internal medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ayeshah HussainDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Iffat AlamDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Devendra K AgrawalDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.ORCID 0000-0001-5445-0013

Funding

Research Education Program to Promote Diversity in Immunologic and Allergic DiseasesR25AI179582 · WESTERN UNIVERSITY OF HEALTH SCIENCES · 2025 to 2025
$379k
NIAID NIH HHS R25 AI179582
6 · The paper itself

Abstract

Alzheimer's disease (AD) remains a major global health crisis due to its complex pathophysiology and limited therapeutic effectiveness. Despite advances in understanding key mechanisms such as amyloid-beta accumulation, tau pathology and neuroinflammation, current therapies provide limited clinical benefit. Multiple factors contribute to limitations and highlight the difficulty of translating scientific advancements into meaningful improvement in patient outcomes. This article provides a comprehensive and critical review of therapeutic, biological, clinical, and systemic barriers to effective Alzheimer's disease management as well as showcasing emerging strategies aimed to improve early detection, treatment approaches, and overall disease prevention.

Indexed as

Acetylcholinesterase inhibitorsAlzheimer’s disease (AD)Amyloid-betaAmyloid plaquesAPOE4BiomarkersBlood-brain-barrier (BBB)Caregiver burdenClinical trialsCognitive declineDiagnostic limitationsDisease-modifying therapiesMemantineMicroglial activationMonoclonal antibodiesNeurodegenerationNeurofibrillary tanglesNeuroinflammationNeuronal lossSymptomatic treatmentSynaptic dysfunctionTau protein

Identifiers

PMID42389758
PMCPMC13322340

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.