ReviewArteriosclerosis, thrombosis, and vascular biology2026
Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.
Review in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Pulmonary vascular development requires coordinated growth, remodeling, and specialization of the endothelial network to support airway branching and alveolar formation. Recent advances in single-cell and spatial transcriptomics have revealed that endothelial cells are organized along a transcriptional arteriovenous spectrum while simultaneously adopting region-specific identities within the capillary bed. In particular, the emergence of distinct alveolar capillary populations, including capillary endothelial cell type 1 and capillary endothelial cell type 2 cells, highlights previously unappreciated heterogeneity. Parallel studies further demonstrate that macrovascular and microvascular identities are influenced by positional context, vessel caliber, and flow-associated transcriptional programs. Together, these insights redefine how endothelial specialization is established during lung development. Here, we review current understanding of pulmonary vascular morphogenesis, endothelial fate specification, and capillary diversification and discuss how emerging imaging platforms may help connect molecular identity with spatial organization and dynamic cellular behavior.
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