SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Association of Protein C, but Not Protein S or Antithrombin With Ischemic Stroke: Bidirectional Two-Sample Mendelian Randomization and Meta-Analysis.
Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
AimTo explore the causal effects of protein C and protein S on ischemic stroke (IS) risk.MethodsEmploying a two-sample bidirectional Mendelian randomization (MR) framework, we investigated the causal association between protein C, protein S and anti-thrombin with ischemic stroke and further performed the mediating analysis based on several risk factors for IS. Then, systematic review and meta-analysis of relevant literature was conducted to validate the association between protein C and ischemic stroke.ResultsGenetic data from a genome-wide association study involving 440,328 individuals, including 34,217 IS patients and 406,111 controls, revealed odds ratios for IS per standard deviation (SD) increases of 0.918 (95% CI: 0.884-0.954; P=1.027e-05) for protein C, 0.997 (95% CI: 0.986-1.035; P=1.027e-05) for protein S, and 0.990 (95% CI: 0.895-1.094; P=8.383e-01) for anti-thrombin (three anticoagulation factor). Mediation analysis indicated that body mass index (BMI) partially mediated this effect, with a mediated proportion of 5.88% (95% CI, 2.236% to 7.232%). In the meta-analysis of 2107 IS patients and 12209 healthy controls, we found that patients with decreased protein C had a significantly higher risk of IS compared with controls (risk ratio: 5.47; 95% CI 3.33, 9.00).ConclusionThese findings suggest a potential relationship between protein C and ischemic stroke and BMI mediates this causal relationship, which might offer prevention strategies targeting protein C and ischemic stroke.
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