Evidence map›Paper›PMID 42390106›Full record

ArticleInfection and immunity2026

The cholesterol-dependent cytolysin promotes

Linya Xia, Xingyu Tian, Chen Yuan, Zhaoxuan Zhu, Fei Pan, Hongjie Fan, Karthik Hullahalli, Matthew K Waldor, Zhe Ma

Abstract read
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linya Xia *Ministry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0003-0570-4237
Xingyu Tian *Ministry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Chen YuanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Zhaoxuan ZhuMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Fei PanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Hongjie FanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0002-3001-0133
Karthik HullahalliDivision of Infectious Diseases, Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3064-2090
Matthew K WaldorDivision of Infectious Diseases, Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Zhe MaMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0002-5212-5759

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Fundamental Research Funds for the Central Universities KJJQ2025003; QTPY2026006Howard Hughes Medical InstituteJiangsu Agricultural Science and Technology Innovation Fund CX(23)1041National Key Research and Development Program of China 2021YFD1800404National Natural Science Foundation of China 32273009, 31973004Natural Science Foundation of Jiangsu Province BK20250095NIAID NIH HHS R01 AI042347NIH HHS R01-AI-042347Priority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itself

Abstract

Streptococcal peritonitis is associated with a high mortality risk and sometimes accompanied by streptococcal toxic shock-like syndrome (STSLS). Here, we used a murine intraperitoneal model of

Indexed as

Arachidonic AcidCholesterolCytotoxinsHemolysin ProteinsPeritonitisStreptococcal InfectionsStreptococcus suisAnimalsDisease Models, AnimalFemaleMiceArachidonic AcidCholesterolCytotoxinsHemolysin Proteinssuilysinacute deatharachidonic acidbottleneckStreptococcus suis serotype 2suilysin

Identifiers

PMID42390106
PMCPMC13367039

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.