ArticleAmerican journal of physiology. Renal physiology2026
Renovascular disease induces functionally relevant, locus-specific alterations to DNA methylation and hydroxymethylation in swine scattered tubular-like cells.
Vinaya C Iyer, Kumar Shivam, Sara Kazeminia, Xiang-Yang Zhu, Hui Tang, Ailing Xue, Sandra Herrmann, Alejandro R Chade, Maria V Irazabal, Lilach O Lerman and 1 more
Abstract read
In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Vinaya C IyerDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Kumar ShivamDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Sara KazeminiaDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2621-9962 Xiang-Yang ZhuDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Hui TangDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Ailing XueDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Sandra HerrmannDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Alejandro R ChadeDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States.
Maria V IrazabalDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-9904-7778 Lilach O LermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-3271-3887 Alfonso EirinDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-3864-9644 Funding
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI Lilach O Lerman · 2021 to 2022
$1.3MRole of mitochondrial microRNAs (mitomiRs) in endogenous renal repairR01DK129240 · NIDDK · MAYO CLINIC ROCHESTER · 2024 to 2025
$897kObesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · MAYO CLINIC ROCHESTER · 2025 to 2025
$692kA new large pre-clinical model of aging-related heart failure: a platform to develop new therapies for HFpEFR21AG084154 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI Alejandro Roberto Chade · 2023 to 2023
$460kHHS | National Institutes of Health (NIH) AG084154HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL158691HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK118391HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK120292HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK128017HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK129240NHLBI NIH HHS R01 HL158691NIA NIH HHS R21 AG084154NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R01 DK128017NIDDK NIH HHS R01 DK129240NIDDK NIH HHS R21 DK118391Regenerative Medicine Minnesota (RMM) RMM 091620 DS 004
6 · The paper itselfAbstract
Scattered tubular-like cells (STCs) are dedifferentiated renal tubular cells that repair other damaged kidney cells. STCs may be damaged and rendered ineffective by renovascular disease (RVD), but the underlying mechanisms remain unknown. We hypothesized that RVD induces changes in methylated (5mC) and hydroxymethylated (5hmC) DNA and modulates the transcriptomic profile and functional properties of swine STCs. CD24+/CD133+ STCs were harvested from pig kidneys after 10 wk of RVD or sham (
Indexed as
DNA MethylationEpigenesis, GeneticEpithelial CellsKidney Tubules5-MethylcytosineAnimalsApoptosisCell DedifferentiationCell ProliferationCells, CulturedSus scrofaSwineTranscriptome5-hydroxymethylcytosine5-Methylcytosine5hmC5mCepigeneticsMeDIP-seqscattered tubular-like cells
Identifiers
PMID42390182
PMCPMC13430535
What Socratic holds
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