Evidence map›Paper›PMID 42390230›Full record

ReviewmBio2026

mGem: A tale as old as blood-do tick-borne pathogens exploit arthropod antioxidant defenses?

Kaylee A Vosbigian, Chelsea A Osbron, Brianna P Steiert, Cameron G Coyle, Ashley L Warren, Dana K Shaw

Abstract readReview
In one paragraph

Review in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kaylee A VosbigianDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-2865-7031
Chelsea A OsbronDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Brianna P SteiertDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-7992-004X
Cameron G CoyleDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Ashley L WarrenDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Dana K ShawDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-5212-2494

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Infectious Diseases and Microbial Immunology Training ProgramT32AI007025 · NIAID · WASHINGTON STATE UNIVERSITY · PI Thomas H KAWULA, M KARIUKI NJENGA · 1985 to 2026
$7.4M
Tick-Pathogen Interactions: Exploring the Intersection between Stress Responses and ImmunityR01AI162819 · NIAID · WASHINGTON STATE UNIVERSITY · PI SHAW, DANA KATHLEEN · 2022 to 2025
$2.0M
NIAID NIH HHS R01 AI162819NIAID NIH HHS T32 AI007025NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Effective control of tick-borne disease begins by first understanding how ticks acquire, harbor, and transmit pathogens. Over their lifetime, ticks encounter many sources of oxidative stress-inducing stimuli. Here, we explore the factors contributing to oxidative stress in ticks-including blood digestion, pesticide exposure, and pathogen infection-and then discuss how ticks counter this stress by employing antioxidant defenses. We highlight how non-tick-borne pathogens manipulate the host antioxidant response for survival and speculate that tick-borne pathogens may be acting similarly in the arthropod. We conclude by conjecturing that the robust antioxidant defenses that ticks have evolved to withstand the stress associated with hematophagy may also be inadvertently supporting the pathogens they carry.

Indexed as

AntioxidantsHost-Pathogen InteractionsOxidative StressTick-Borne DiseasesTicksAnimalsHumansAntioxidantsantioxidantsarthropod vectorshost-pathogen interactionsoxidative stresstick-borne pathogensvector-borne diseases

Identifiers

PMID42390230
PMCPMC13464024

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.