Evidence map›Paper›PMID 42390646›Full record

ArticleMolecular neurobiology2026

Hypothalamus Amyloid Levels Are Associated with Early Sex-Dependent Alterations in Peripheral Energy Homeostasis in TgF344-AD Rats.

Caleb M Levine, Cameron Caggiano, Thea Anderson, Michael A Kelberman, David Weinshenker, Hannah L Lail, Desiree Wanders, Debra A Bangasser, Scott E Kanoski, Marise B Parent

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Caleb M LevineNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA.
Cameron CaggianoNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA.
Thea AndersonNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA.
Michael A KelbermanDepartment of Human Genetics, Emory School of Medicine, Whitehead Biomedical Research Building, 615 Michael St, Suite 301, Atlanta, GA, 30322, USA.
David WeinshenkerDepartment of Human Genetics, Emory School of Medicine, Whitehead Biomedical Research Building, 615 Michael St, Suite 301, Atlanta, GA, 30322, USA.
Hannah L LailDepartment of Nutrition, Georgia State University, Urban Life Building, PO Box 4019, Atlanta, GA, 30302-4019, USA.
Desiree WandersNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA.
Debra A BangasserNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA.
Scott E KanoskiHuman and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, 3616 Trousdale Parkway, AHF-252, Los Angeles, CA, 90089-0372, USA.
Marise B ParentNeuroscience Institute, Petit Science Center, Georgia State University, PO Box 5030, Atlanta, GA, 30302-5030, USA. mbparent@gsu.edu.ORCID http://orcid.org/0000-0001-7862-5623

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported previously that diet-induced obesity exacerbates early-stage Alzheimer's disease (AD)-like pathology in TgF344-AD rats. Those findings also suggested that they may be prone to weight gain during early AD development, raising the possibility of early hypothalamic dysfunction. In this study, we investigate this by determining whether hypothalamic soluble amyloid-β

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesEnergy MetabolismHomeostasisHypothalamusPeptide FragmentsSex CharacteristicsAdipose Tissue, BrownAnimalsFemaleGlucoseMaleRats, TransgenicUncoupling Protein 1Amyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)GlucosePeptide FragmentsUncoupling Protein 1Alzheimer’s diseaseBlood glucoseBrown adipose tissueMetabolismUncoupling 1 protein

Identifiers

PMID42390646
PMCPMC13328149

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.