ArticleJournal of molecular histology2026
The protective role of vitamin E against omeprazole-induced liver alterations in male wistar rats (Rattus norvegicus).
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Due to the limited information available regarding the effect of Omeprazole (OM) on rats' liver function. This study aimed to elucidate the impact on liver morphology, hepatic enzymes, liver weight, and electrolytes in male Wistar rats. Fifty rats were randomly allocated into five groups (n = 10): control, OM (5 mg/kg/day), OM + Vit. E (5 mg/kg/day each), Vit. E alone (5 mg/kg/day each), and a recovery group (5 mg/kg/day each), for 28 days. Biochemical analysis evaluated hepatic enzymes (ALP, AST, ALT) and serum electrolytes. Histological examination of hepatic tissues was performed using H&E, PAS, and Masson's Trichrome staining. OM significantly increased ALP (177.56 U/L), AST (145.2 U/L), and ALT (47.8 U/L) compared with controls (P ≤ 0.05). Co-administration of Vit E effectively attenuated these elevations, while the recovery group demonstrated only partial normalization. OM also significantly reduced liver weight, altered liver shape, and disrupted Cl
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