Evidence map›Paper›PMID 42390711›Full record

ArticleBiogerontology2026

MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures.

Ekaterina Rudnitsky, Naomy Vineshtock, Natali Yakubov, Alex Braiman, Yael Segev, Marina Wolfson, Khachik K Muradian, Vera Gorbunova, Gadi Turgeman, Michaela Ben Shahar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ekaterina Rudnitsky *The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel. rudnitsk@bgu.ac.il.
Naomy Vineshtock *The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Natali YakubovThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Alex BraimanThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Yael SegevThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Marina WolfsonThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Khachik K MuradianDepartment of Biology of Aging and Experimental Life Span Extension, State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, 4114, Ukraine.
Vera GorbunovaDepartments of Biology and Medicine, Rochester Aging Research Center, University of Rochester, Rochester, NY, 14627, USA.
Gadi TurgemanDepartment of Molecular Biology, Faculty of Natural Sciences and The Adelson School of Medicine, Ariel University, 40700, Ariel, Israel.
Michaela Ben ShaharDepartment of Molecular Biology, Faculty of Natural Sciences and The Adelson School of Medicine, Ariel University, 40700, Ariel, Israel.
Vadim E FraifeldThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.

Funding

United States-Israel Binational Science Foundation 2021287
6 · The paper itself

Abstract

Wound healing (WH) is a multi-component and highly orchestrated process, in which fibroblasts play a pivotal role. Wound healing is commonly attenuated during aging and the course of cellular senescence (CS). A growing body of evidence demonstrates that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) can mitigate the aging and CS phenotype. In this study, we evaluated the effects of EVs derived from naïve MSCs (nMSCs) or anti-inflammatory polarized MSCs (pMSCs) on the rate of in vitro wound healing in primary cultures of human pulmonary fibroblasts (HPF) at various stages of cellular senescence. The major finding of this study is that MSC-derived EVs increase the rate of in vitro WH in senescent but not young HPF cultures. Yet, the pMSC-derived EVs had a stronger impact on WH acceleration in senescent cultures as compared to the nMSC-derived EVs, and this impact was apparently attributed to cell migration.

Indexed as

Cellular SenescenceExtracellular VesiclesFibroblastsMesenchymal Stem CellsWound HealingCell MovementCells, CulturedHumansCellular senescenceExtracellular vesicles (EVs)FibroblastsMesenchymal stem cells (MSCs)Wound healing

Identifiers

PMID42390711
PMCPMC13328317

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.