Evidence map›Paper›PMID 42390988›Full record

ArticleDiabetes2026

Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.

Subhasmita Rout, Takuya Karasawa, Shinya Watanabe, Amandine Chaix, Micah J Drummond, Katsuhiko Funai, Ran Hee Choi

Abstract read
PubMed Publisher
In one paragraph

Article in Diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Subhasmita RoutDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Takuya KarasawaDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Shinya WatanabeDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Amandine ChaixDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Micah J DrummondDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Katsuhiko FunaiDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.ORCID 0000-0003-3802-4756
Ran Hee ChoiDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.ORCID 0000-0001-9002-2657

Funding

NIH HHS AG065993NIH HHS AG074535NIH HHS CA278826NIH HHS CA286584NIH HHS DK107397NIH HHS DK110858NIH HHS DK127979NIH HHS GM144613Society for Promotion of Science (JSPS) 24KJ2039
6 · The paper itself

Abstract

article highlightsFemale C57BL/6 J mice are relatively resistant to weight gain, which complicates the study of sex-specific metabolic responses. So, we used ob/ob mice to examine semaglutide-induced weight loss in both sexes. We wanted to determine whether semaglutide-induced weight loss produces sex-specific effects on skeletal muscle mass and function in ob/ob mice. Semaglutide had minimal effects on skeletal muscle mass and strength in ob/ob mice. In particular, females were completely resistant to loss of muscle mass. These findings reveal that semaglutide exerts sex-specific effects, highlighting a need for further research into the molecular mechanisms driving these distinct protective outcomes.

Identifiers

PMID42390988

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.