Evidence map›Paper›PMID 42392083›Full record

ArticleStem cell reports2026

Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis.

Xue Li, Guiying Xu, Qi Wang, Qingwen Ma, Xue Liu, Hongwei Li, Sisi Wang, Yimeng Liu, Yueyue Jin, Xuan Miao and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xue LiTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Guiying XuTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Qi WangDepartment of Stomatology, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Qingwen MaDepartment of Laboratory Medicine, Tianjin Hospital, Tianjin University, Tianjin 300350, China.
Xue LiuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Hongwei LiDepartment of Respiratory and Critical Care, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Sisi WangDepartment of Respiratory, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China.
Yimeng LiuTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Yueyue JinState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Xuan MiaoDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Zuokuan HeDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Jinrui DongAcademy of Medical Engineering and Translational Medicine, School of Medicine, Tianjin University, Tianjin 300072, China.
Kuan LiTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Jianhai WangTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Yu LiTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Qiuyang ZhangTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Dianhua JiangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Junping WuTianjin Institute of Respiratory Diseases, Tianjin 300350, China. Electronic address: wujp0618@126.com.
Wen NingState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: ningwen108@nankai.edu.cn.
Huaiyong ChenTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China; Tianjin Institute of Respiratory Diseases, Tianjin 300350, China. Electronic address: huaiyong.chen@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung fibrosis progression is marked by impaired alveolar epithelial regeneration and uncontrolled myofibroblast differentiation, though the underlying mechanisms remain poorly understood. In this study, we discovered that Atg5 was upregulated in the mesenchymal cells of lungs from both patients with idiopathic pulmonary fibrosis (IPF) and mice with bleomycin (BLM)-induced fibrosis. Selective deletion of Atg5 in lung mesenchymal cells increased the susceptibility of mice to BLM-induced lung fibrosis. Mechanistically, the loss of Atg5 promoted transforming growth factor β 1 (TGF-β1)-induced oxidative stress and cellular senescence in fibroblasts, myofibroblast differentiation, and extracellular matrix deposition. Intriguingly, loss of Atg5 impaired the secretion of tissue repair-favoring factors in fibroblasts, causing defects in the proliferation and differentiation of alveolar type 2 cells. This study showed that Atg5 is essential for alveolar epithelial repair and myofibroblast control in lung fibrosis.

Indexed as

Autophagy-Related Protein 5MyofibroblastsPulmonary AlveoliPulmonary FibrosisRegenerationAlveolar Epithelial CellsAnimalsBleomycinCell DifferentiationCell ProliferationCellular SenescenceHumansIdiopathic Pulmonary FibrosisMiceOxidative StressTransforming Growth Factor beta1Autophagy-Related Protein 5BleomycinTransforming Growth Factor beta1alveolar epithelial progenitor cellsmyofibroblast differentiationorganoid culturespulmonary fibrosisTbx4

Identifiers

PMID42392083
PMCPMC13385427

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.