Evidence map›Paper›PMID 42393009›Full record

ArticleAddiction biology2026

Abuse Potential and Neurotoxic Effects of the Synthetic Cannabinoid 4F-ABUTINACA Self-Administration in Adult Male Rats.

Baobao Shi, Huizhen Liu, Manqing Wu, Yuting Wang, Dan Fu, Lili Wen, Huifen Liu, Peng Xu, Wenhua Zhou, Haitao Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Baobao ShiSchool of Psychology and Mental Health, North China University of Science and Technology, Tangshan, Hebei Province, China.
Huizhen LiuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Manqing WuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuting WangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Dan FuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Lili WenDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Huifen LiuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Peng XuOffice of China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Beijing, China.
Wenhua ZhouDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Haitao WangSchool of Psychology and Mental Health, North China University of Science and Technology, Tangshan, Hebei Province, China.
Miaojun LaiDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

National Key R&D Program of China 2022YFC3300905National Natural Science Foundation of China 82471516Ningbo Public Welfare Research Project 2024S025Ningbo Top Medical and Health Research Program 2022030410
6 · The paper itself

Abstract

4F-ABUTINACA, a fourth-generation synthetic cannabinoid, has been identified in branded herbal smoking mixtures and e-cigarettes seized in China. However, its potential for abuse and its corresponding neurotoxic effects remain poorly understood. In the present study, we evaluated the abuse potential of 4F-ABUTINACA using the intravenous self-administration (IVSA) model and assessed anxiety-like behaviour using the open-field test (OFT) and the elevated plus maze test (EPM). Additionally, neuronal injury, apoptosis, alterations in glia expression and the BDNF-TrkB-AKT signalling pathway in multiple brain regions were assessed simultaneously. Rats acquired stable nose-poke operant response for self-administering 4F-ABUTINACA (0.00625 mg·kg

Indexed as

CannabinoidsSubstance-Related DisordersAnimalsAnxietyApoptosisBehavior, AnimalBrainBrain-Derived Neurotrophic FactorConditioning, OperantDrug-Seeking BehaviorHippocampusMaleNucleus AccumbensPrefrontal CortexRatsRats, Sprague-DawleyBdnf protein, ratBrain-Derived Neurotrophic FactorCannabinoids4F‐ABUTINACAabuse potentialintravenous self‐administrationneurotoxic effectssynthetic cannabinoid

Identifiers

PMID42393009
PMCPMC13327829

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.