Evidence map›Paper›PMID 42393021›Full record

ArticleCell death & disease2026

Small molecule-mediated activation of Notch signal transduction.

Subhamita Dey, Benedetto Daniele Giaimo, Iva Katharina Zöllner, Qingwen Yang, Hina Zarrin, Jasmin Ballout, Martin Diener, Tobias Friedrich, Francesca Ferrante, Jan Dreute and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Subhamita Dey *Institute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.
Benedetto Daniele Giaimo *Institute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0003-0384-325X
Iva Katharina ZöllnerDepartment of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.
Qingwen YangDepartment of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0002-9746-8317
Hina ZarrinDepartment of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0009-0007-2945-104X
Jasmin BalloutInstitute of Veterinary Physiology and Biochemistry, Justus-Liebig University, Giessen, Germany.
Martin DienerInstitute of Veterinary Physiology and Biochemistry, Justus-Liebig University, Giessen, Germany.
Tobias FriedrichInstitute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0003-4014-8678
Francesca FerranteInstitute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.
Jan DreuteInstitute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-4708-2678
M Lienhard SchmitzInstitute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-6984-7192
Astrid WeissDepartment of Internal Medicine II, Universities of Giessen and Marburg Lung Center, University Hospital Giessen, Justus Liebig University, Giessen, Germany.ORCID http://orcid.org/0000-0002-1788-2666
Pierfrancesco PoloCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany.
Matthias LauthCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0001-5922-5384
Bernd GahrMolecular Cardiology, Department of Internal Medicine II, Ulm University, Ulm, Germany.ORCID http://orcid.org/0000-0002-5755-6603
Steffen JustMolecular Cardiology, Department of Internal Medicine II, Ulm University, Ulm, Germany.ORCID http://orcid.org/0000-0001-7396-1281
Marek BartkuhnBiomedical Informatics and Systems Medicine, Justus-Liebig University, Giessen, Germany.ORCID http://orcid.org/0000-0001-6872-9082
Franz OswaldDepartment of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0002-2923-5765
Tilman BorggrefeInstitute of Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany. tilman.borggrefe@biochemie.med.uni-giessen.de.ORCID http://orcid.org/0000-0003-4325-5452

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) TRR81
6 · The paper itself

Abstract

The Notch signaling pathway is pivotal in regulating cell differentiation, stem cell maintenance and oncogenesis. While several Notch inhibitors have been developed, effective small molecule activators are scarce. Here, we identify a small molecule that robustly activates Notch signaling, leading to significant upregulation of Notch target genes in several human cell lines and in Danio rerio embryos. Mechanistically, this compound induces the expression of activated NOTCH3 protein via a cryptic internal promoter within the NOTCH3 locus. Notch induction is markedly diminished upon genetic depletion of NOTCH3 or the canonical Notch transcription factor RBPJ. Furthermore, we demonstrate that the compound inhibits complex I of the respiratory chain. This is accompanied by a raise of cytosolic Ca

Indexed as

Receptors, NotchSignal TransductionSmall Molecule LibrariesAnimalsCalciumCell DifferentiationCell Line, TumorHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinPromoter Regions, GeneticReceptor, Notch3ZebrafishCalciumImmunoglobulin J Recombination Signal Sequence-Binding ProteinReceptor, Notch3Receptors, NotchSmall Molecule Libraries

Identifiers

PMID42393021
PMCPMC13396519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.