Evidence map›Paper›PMID 42393024›Full record

ArticleTranslational psychiatry2026

Natural flavonoid dihydroquercetin blocks Trim14-JAK1-STAT3 signaling and relieves pain-depression comorbidity in rheumatoid arthritis.

Xiao-Wei Ni, Bin Chai, Zi-Meng Li, Xin-Pei Li, Chen Sun, Xiao-Ling Yuan, Ya-Bin Zhang, Yan Zhang, Wen-Juan Qian, Hai-Long Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao-Wei Ni *Department of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China.
Bin Chai *Department of Orthopedics, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Zi-Meng Li *Center of Translational Medicine, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou, 215123, China.
Xin-Pei LiDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China.
Chen SunDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China.
Xiao-Ling YuanDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China.
Ya-Bin ZhangDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China.
Yan ZhangDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China. 55371612@qq.com.
Wen-Juan QianDepartment of Rheumatology and Immunology, Center for Translational Medicine, Zhangjiagang Hospital affiliated to Soochow University, Suzhou, 215600, China. 1404022809@qq.com.
Hai-Long ZhangCenter of Translational Medicine, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou, 215123, China. hlzhang76@suda.edu.cn.ORCID http://orcid.org/0000-0002-8720-2734

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82201575
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is frequently complicated by chronic pain, anxiety and depression, yet the neuroimmune mechanisms linking peripheral inflammation to central affective dysfunction remain elusive. Here we demonstrate that the natural flavonoid dihydroquercetin (DHQ) blocks Trim14 and relieves pain-depression comorbidity in RA. Serum Trim14 is elevated in RA patients and correlates with clinical symptom severity. We identify Trim14 as a contributing factor of JAK1/STAT3 signaling in spinal dorsal horn neurons, promoting both nociceptive sensitization and affective symptoms in collagen-induced arthritis (CIA) mice. Intrathecal Trim14 siRNA attenuates synovial inflammation, inflammatory pain and anxiety-depressive behaviors. Molecular docking and molecular dynamics simulations reveal that DHQ occupies the Trim14 PRYSPRY substrate-recognition pocket with sub-micromolar affinity. Long-term DHQ treatment improves both nociceptive and affective symptoms by inhibiting spinal Trim14-JAK1-STAT3 axis in CIA mice. These findings suggest Trim14 as a potential neuroimmune target and DHQ as a natural medicine modulator for pain-depression comorbidity in chronic inflammatory disease.

Indexed as

Arthritis, RheumatoidDepressionJanus Kinase 1PainQuercetinSTAT3 Transcription FactorAnimalsComorbidityHumansMaleMiceMolecular Docking SimulationPosterior Horn CellsSignal TransductionTripartite Motif ProteinsJak1 protein, mouseJanus Kinase 1QuercetinStat3 protein, mouseSTAT3 Transcription FactortaxifolinTripartite Motif Proteins

Identifiers

PMID42393024
PMCPMC13498594

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.