Evidence map›Paper›PMID 42393268›Full record

ReviewCommunications medicine2026

Evidence and opportunities for preeclampsia and cardiovascular disease prevention in malaria endemic settings.

Ifeoma M Obionu, Julie M Moore, Safiya Zahradeen, Hadiza Galadanci, Mark D Huffman, Zainab Mahmoud

Abstract readReview
In one paragraph

Review in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ifeoma M ObionuCardiovascular Division and Global Health Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Julie M MooreDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-5031-3270
Safiya ZahradeenMuhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.
Hadiza GaladanciAfrican Center of Excellence for Population Health and Policy, College of Health Sciences, Bayero University, Kano, Nigeria.
Mark D HuffmanCardiovascular Division and Global Health Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7412-2519
Zainab MahmoudCardiovascular Division and Global Health Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. zmahmoud@wustl.edu.ORCID http://orcid.org/0000-0002-5203-2253

Funding

Exploring the etiology of oxidative damage and cell death in placental malariaR01AI168923 · NIAID · UNIVERSITY OF FLORIDA · PI JULIE M MOORE · 2022 to 2026
$1.9M
NIAID NIH HHS R01 AI168923
6 · The paper itself

Abstract

Sub-Saharan Africa bears a high burden of both malaria in pregnancy and hypertensive disorders of pregnancy including preeclampsia, a leading cause of maternal and perinatal deaths. Increasing evidence suggests that infection with Plasmodium falciparum, which causes placental malaria, is associated with increased preeclampsia risk. Here we discuss how epidemiologic and biological evidence link malaria to preeclampsia by examining shared pathways, including placental inflammation and vascular disruptions, which culminate in the unifying phenomenon of placental dysfunction in both syndromes. With these shared mechanisms in mind, we discuss how malaria prevention strategies could reduce the risk of preeclampsia and related long-term cardiovascular disease in endemic settings. We also outline key research and implementation priorities to support integrated prevention approaches in affected settings.

Identifiers

PMID42393268
PMCPMC13328712

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.