Observational studyJournal of assisted reproduction and genetics2026
Another round, another chance: oocyte developmental competence and outcomes in second IVF attempts-the earlier, the better.
Observational study in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate whether the outcomes and characteristics of a first IVF/ICSI cycle are associated with embryological and clinical outcomes in a subsequent cycle performed within 2 years.
methodsThis retrospective single-center observational study included 1190 couples undergoing two stimulated ICSI cycles with planned blastocyst culture between 2015 and 2020. Associations between first- and second-cycle outcomes were analyzed, including oocyte yield, blastocyst development, and live birth. The effect of the inter-cycle interval was assessed using multivariate models.
resultsThe mean maternal age was 38.7 years, and the mean AMH level was 1.7 ng/ml. Second cycles showed improved embryological outcomes, including higher numbers of retrieved cumulus-oocyte complexes (COCs), increased blastocyst yield, and higher blastocyst rate per COC. Overall, 50% of patients retrieved more COCs in the second cycle, and 87% of those with no COCs in the first cycle obtained ≥ 1 in the second. A longer inter-cycle interval was negatively associated with outcomes, reducing the likelihood of retrieving more COCs (OR 0.96 per month, 95% CI 0.93-0.98), obtaining more blastocysts (OR 0.95, 95% CI 0.93-0.98), and improving blastocyst rate (OR 0.96, 95% CI 0.94-0.99). First-cycle outcomes were not associated with live birth probability in the second cycle, which was instead associated with maternal age and the number of COCs previously retrieved.
conclusionsFirst-cycle outcomes should not discourage further attempts, as subsequent cycles may yield improved embryological results. A shorter interval between cycles represents a modifiable factor associated with better outcomes. These findings support early re-treatment and a multicycle counseling approach to optimize cumulative live birth rates, especially as maternal age and ovarian reserve remain the most important predictors of success even in second attempts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.