Evidence map›Paper›PMID 42393405›Full record

ArticleDiabetologia2026

GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study.

Rasmus S Rasmussen, Sophie W Nielsen, Lotte Alstrup, Tanne S W Larsson, Jonathan K Hansen, Rune P Pedersen, Mark B Vestergaard, Bryan Haddock, Helle H Johannesen, Henrik B W Larsson and 6 more

Registry-linked trialAbstract read
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In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06426823 (The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06426823 nacompletednot on this map

The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes

TypeinterventionalSponsorUniversity of CopenhagenRan2023 to 2026Enrolled10ConditionsBlood FlowArmsSaline / placebo, GIPR antagonist / study tool
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rasmus S RasmussenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0002-5892-7859
Sophie W NielsenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0002-5934-038X
Lotte AlstrupDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Tanne S W LarssonDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Jonathan K HansenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
Rune P PedersenDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Mark B VestergaardDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Bryan HaddockDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Helle H JohannesenDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Henrik B W LarssonDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.
Jens J HolstDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
Bolette HartmannDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
Mette M RosenkildeDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0001-9600-3254
Ali AsmarDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.ORCID http://orcid.org/0000-0002-0530-827X
Ulrik B AndersenDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Glostrup, Denmark.ORCID http://orcid.org/0000-0003-2214-0496
Lærke S GasbjergDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark. lsg@sund.ku.dk.ORCID http://orcid.org/0000-0002-7880-8515

Funding

Novo Holdings NNF18SA0034956
6 · The paper itself

Abstract

aims/hypothesisIn healthy lean humans, endogenous glucose-dependent insulinotropic polypeptide (GIP) contributes significantly to the postprandial increase in arteria mesenterica superior blood flow. The vascular biology related to activation of the GIP receptor is markedly impaired in individuals with type 2 diabetes and is sometimes absent. In this population, we investigated the role of endogenous GIP on postprandial splanchnic blood flow by using the GIP receptor antagonist, GIP(3-30)NH

methodsTen participants with type 2 diabetes (age 20-80 years, BMI 20-35 kg/m

resultsOral glucose alone increased mean blood flow in arteria mesenterica superior by 57% (95% CI 26, 88) and this was 15% (95% CI -2, 32) lower during concomitant GIP receptor antagonist infusion, p=0.012. Infusion of GIP receptor antagonist during oral glucose treatment did also result in lower insulin secretion, C-peptide and C-peptide/glucose ratio compared with saline infusion, whereas glucagon levels and plasma glucose were unaffected. Oral water did not affect any outcomes. CONCLUSIONS/

interpretationEndogenous GIP contributes to postprandially increased splanchnic blood flow in people with type 2 diabetes.

trial registrationClinicalTrials.gov NCT06426823

fundingThis work was supported by the Novo Nordisk Foundation.

Indexed as

EndocrinologyGIPGut hormonesHaemodynamicIncretin hormonesPostprandial metabolism

Identifiers

PMID42393405

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.