Evidence map›Paper›PMID 42393428›Full record

ArticleGeroScience2026

PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.

Ajla Hodzic Kuerec, Lihuan Guan, Weilan Wang, Duarte Barros, Wejdan M Alenezi, Jozo Grgic, Vanessa K Wazny, Jordi Morwani-Mangnani, Mazzarine Dotou, Dingding Zhang and 27 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Ajla Hodzic Kuerec *NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Lihuan Guan *NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Weilan Wang *NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Duarte BarrosNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Wejdan M AleneziNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Jozo GrgicNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Vanessa K WaznyNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Jordi Morwani-MangnaniNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Mazzarine DotouNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Dingding ZhangNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Tong ChenNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Jiaqiu WangNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Jane Yu Ying OngNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Jian Hua TayNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Natasha To-AnanNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Christian R SoteloNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Atikah D Binti Naseer KhanNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Wester BrugginkNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Sabarinath V NairNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Saiful A Bin Mohamed SukorNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Shivaji RikkaNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Renee Chng Yee SinNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Hui Min ChongNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Faiz Bin Mohamed HashimNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Sharon N Binte Shahul HameedNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Anees B Binte Abdul HamidNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Xin JinNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Carmina FusterNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Yong ChenNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore.
Anna MilaniSparkd By Chi Longevity, Singapore, 068893, Singapore.
Cuilin ZhangGlobal Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
Paul MacaryDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Timothy R SinghamDepartment of Psychology, National University of Singapore, Singapore, Singapore.
Karishma SachaphibulkijLife Sciences Institute, National University of Singapore, Singapore, 119077, Singapore.
Michael DunnCentre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Lin YiAbinopharm, Inc, 3 Enterprise Drive, Suite 407, Shelton, CT, 06484, USA.
Andrea B MaierNUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117456, Singapore. a.b.maier@vu.nl.ORCID http://orcid.org/0000-0001-7206-1724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 middle-aged-to-older participants who received a multimodal intervention comprising fundamental and augmented interventions. The fundamental interventions include sleep and dietary recommendations; supplementation with whey protein, creatine, and fucoidan; supervised exercise with an exergaming component (dual-task cognitive-physical training); motivational interviewing; and cognitive behavioural therapy. The augmented intervention is further personalised based on predefined gerotypes, reflecting individual ageing patterns beyond chronological age. At baseline, urolithin A, nicotinamide mononucleotide, and/or multivitamin-multimineral were prescribed to participants based on their muscle mass, VO

Indexed as

GerotypesHealthcarePROMETHEUS

Identifiers

PMID42393428

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.