ReviewMikrochimica acta2026
Nanoparticles-assisted SELEX strategies for aptamer screening: a comprehensive review.
Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aptamers, short oligonucleotide strands hold excellent potential for diverse applications in the field of biomedicine and bioanalytics such as drug delivery, bioimaging, biosensors, therapy and theranostics, thereby emerging as potential alternatives to antibodies. Since the introduction of SELEX (Systematic Evolution of Ligands by Exponential Enrichment) approach to screen and amplify the target specific oligonucleotide strands, extensive research has been conducted on aptamers for their utilization in diagnosis and therapy. Thus with rapid growth in aptamer technology and progress in SELEX approach has led to the development of several SELEX variants to mitigate the difficulties faced by traditional SELEX. One such variant is nanoparticles mediated SELEX which involves the utilization of nanoparticles such as graphene oxide (GO), gold nanoparticles (GNPs), magnetic nanoparticles (MNPs) etc. as supporting matrices to facilitate library immobilization; assay indicators to promote real time monitoring of enrichment, and label free characterization of screened aptamer. In this context, it is imperative to critically review the application of nanoparticles in screening and selection of aptamers towards target molecules. Therefore, the present review firstly details about the structural characteristics of aptamers, the conventional SELEX method and outlines the pros and cons of various advanced SELEX variants. Later, the review emphasizes the nanoparticles-mediated SELEX to provide a holistic view on how the nanoparticles play a critical role in SELEX process for screening the aptamers for diverse analytes viz. toxins, viruses, chemical compounds, pesticides, tumor markers, etc. Finally, the review presents the perspective on the nanoparticle mediated SELEX approach, delineating the challenges faced by this approach and feasible solutions for SELEX improvement.
Indexed as
Identifiers
42393470What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.