Observational studyBMC neurology2026
The relationship between physical activity levels and measures of cognition and disease severity in prodromal Parkinson's disease: A longitudinal study.
Observational study in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01141023 (The Parkinson's Progression Markers Initiative), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Parkinson's Progression Markers Initiative (PPMI)
Who cites it
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity has been studied for its potential role in reducing motor symptoms of Parkinson's disease (PD). However, its impact on its prodromal phase remains underexplored.
methodsWe included 108 people with prodromal PD from the Parkinson's Progression Markers Initiative. We assessed their four-year longitudinal data of Physical Activity Scale for the Elderly, Movement Disorders Society-sponsored revision of the Unified Parkinson's Disease Rating Scale scores 1-3, Hopkins Verbal Learning Test-Revised, Letter-Number Sequencing test, and the Symbol Digit Modalities Test.
resultsOur linear mixed-effects model regression showed that physical activity (as assessed by the total, household-related, leisure-related, and work-related scores) had no significant associations with disease severity and cognitive function (p-values > 0.05).
conclusionsOur study found no significant associations between physical activity levels and cognitive function or PD symptoms. However, methodological limitations of the study suggest the need for further research to better understand the effects of physical activity on prodromal PD.
trial registrationThis study is a secondary analysis of de-identified data obtained from the Parkinson's Progression Markers Initiative (PPMI) observational cohort and did not directly involve prospective participant enrollment or intervention by the investigators. The PPMI study itself was registered on ClinicalTrials.gov (Identifier: NCT01141023) on 2010-06-10.
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