Evidence map›Paper›PMID 42393735›Full record

ArticleJournal of experimental & clinical cancer research : CR2026

Extracellular vesicle-mediated GALNT1/RPRD1A glycosylation axis drives immune escape and peritoneal metastasis in gastric cancer.

Guohua Jin, Jianguang Zhang, Qingying He, Shiyu Chang, Zheyu Dong, Yang Shi

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In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Guohua JinDepartment of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China.
Jianguang ZhangDepartment of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China.
Qingying HeDepartment of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China.
Shiyu ChangDepartment of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China.
Zheyu DongThe First Clinical Medical College of Jilin University, Changchun, 130021, China.
Yang ShiDepartment of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China. shiyang@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal metastasis represents one of the most lethal clinical manifestations of gastric cancer (GC) and is closely associated with immune evasion. Extracellular vesicles (EVs) have emerged as critical mediators of tumor-immune communication; however, the molecular mechanisms by which EV-associated glycosylation regulates immune escape and metastatic dissemination remain largely undefined.

methodsEVs derived from highly metastatic GC cells were isolated and functionally characterized in vitro and in humanized immune system mouse models. Their clinical relevance was evaluated using paired human GC specimens. Underlying mechanisms were investigated through genetic manipulation, lectin-based glycosylation assays, and immune cell co-culture experiments.

resultsWe identified GALNT1 as an EV-enriched glycosyltransferase that promotes GC cell invasion and suppresses CD8

conclusionsThese findings identify an EV-driven GALNT1/RPRD1A glycosylation axis as a previously unrecognized mechanism underlying immune escape and peritoneal metastasis in GC and support this pathway as a potential therapeutic target for advanced disease.

Indexed as

Extracellular VesiclesN-AcetylgalactosaminyltransferasesPeritoneal NeoplasmsStomach NeoplasmsTumor EscapeAnimalsCell Line, TumorFemaleGlycosylationHumansMicePolypeptide N-acetylgalactosaminyltransferaseN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseCD8⁺ T cellsExtracellular vesiclesGALNT1Gastric cancerGlycosylationImmune escapeLipid nanoparticlesPeritoneal metastasisRPRD1A

Identifiers

PMID42393735
PMCPMC13602598

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.