ArticleSystematic reviews2026
Effectiveness of non-pharmacological interventions for post-stroke depression: protocol for an umbrella review of systematic reviews and meta-analyses.
Article in Systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-stroke depression (PSD) is one of the most common neuropsychiatric complications following stroke, affecting approximately one-third of patients and substantially impairing functional recovery, quality of life, and survival. Pharmacological therapies, although commonly used, are limited by adverse effects and potential drug-drug interactions. Non-pharmacological interventions have gained increasing attention as safer alternatives, and numerous systematic reviews and meta-analyses have been published. However, their conclusions remain inconsistent due to methodological variability, heterogeneity, and overlapping evidence. To date, no umbrella review has comprehensively synthesized this evidence.
objectiveTo comprehensively synthesize evidence from systematic reviews and meta-analyses regarding the effectiveness and safety of non-pharmacological interventions for post-stroke depression (PSD).
methodsThis umbrella review will be conducted in accordance with PRISMA-P guidelines. A comprehensive search will be conducted for systematic reviews and meta-analyses evaluating non-pharmacological interventions, either as monotherapy or adjunctive therapy, for the treatment of post-stroke depression (PSD). The following databases will be searched from inception to December 2025: MEDLINE (via PubMed), Embase, Cochrane Database of Systematic Reviews (CDSR), Web of Science, CINAHL, and the major Chinese literature databases (CNKI, WanFang, VIP, SinoMed). No language restrictions will be applied. Search strategies will combine Medical Subject Headings (MeSH) and free-text terms tailored to each database. Reference lists of included reviews will also be screened, and the search will be updated before the final analysis to ensure inclusion of the most recent evidence.
conclusionThis study will provide the first umbrella review of non-pharmacological interventions for PSD. By applying rigorous methodological tools, it aims to deliver a comprehensive and methodologically robust synthesis of current evidence, support clinical decision-making, and identify priorities for future research. SYSTEMATIC REVIEW REGISTRATION: This protocol was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) on September 17, 2025 (registration number: CRD420251149507).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.