ReviewVox sanguinis2026
Barriers and enablers to non-remunerated plasma donation: A meta-synthesis of the qualitative literature using the theoretical domains framework.
Review in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
BACKGROUND AND
objectivesPlasma is an essential component of therapies used to treat immune deficiencies, coagulation disorders and other serious conditions. Despite increasing global demand, many countries, including Canada, remain dependent on imported plasma products. Understanding the psychological, social and structural factors influencing plasma donation is critical to designing strategies that strengthen domestic supply. This meta-synthesis aimed to identify barriers and enablers to plasma donation using the theoretical domains framework (TDF). MATERIALS AND
methodsA systematic search of Medline, Embase, Scopus, PsycINFO and CINAHL (up to August 2023) identified qualitative studies describing experiences and perceptions of plasma donation. Using directed content analysis, qualitative data were coded to TDF domains, and belief statements summarizing barriers and enablers were generated and synthesized narratively.
resultsTwenty studies (n = 1310 participants) conducted in non-remunerated contexts met inclusion criteria. A total of 131 belief statements were mapped to 13 of 14 TDF domains. The largest number occurred in Environmental Context and Resources (e.g., accessibility, scheduling, staff support), followed by Knowledge, Social/Professional Role and Identity, Social Influences, and Emotion. Barriers centred on logistical constraints, limited understanding and negative emotional responses, whereas enablers reflected trust in institutions, supportive staff, identity as a donor and feelings of pride and altruism.
conclusionPlasma donation behaviour is shaped by interacting informational, emotional, social and structural determinants. Addressing practical barriers while leveraging enablers such as donor identity, social support and transparent communication may enhance recruitment and retention. Our findings can inform the design of theory-based, donor-centred interventions to strengthen national plasma collection systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.