ArticleExperimental physiology2026
Divergent skeletal muscle metabolite exchange in insulin-like growth factor-1-stimulated myotubes and resistance-exercised human muscle.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Divergent skeletal muscle metabolite exchange in insulin-like growth factor-1-stimulated myotubes and resistance-exercised human muscle.Experimental physiology · 2026Article
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17 authors.
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Abstract
Skeletal muscle hypertrophy requires a substantial nutrient influx for biomass accretion, but global metabolite exchange during growth is poorly characterized. Therefore, we profiled the metabolite uptake and release in insulin-like growth factor-1 (IGF-1)-stimulated C2C12 myotubes and human muscle 24 h after resistance exercise. Differentiated C2C12 myotubes were stimulated to grow with IGF-1 (100 ng/mL, 24 h) or received vehicle control. To measure metabolite exchange, we analysed fresh and spent media by gas chromatography-mass spectroscopy metabolomics. In a second experiment, seven untrained adults (three males and four females; age 25.6 ± 3.2 years; body mass index 23.8 ± 2.8 kg/m
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