ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Clinical application value of sST2 in patients with heart failure].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesAccurate diagnosis and prognostic assessment of heart failure are crucial for improving patients' quality of life. This study aims to investigate the clinical value of serum soluble growth stimulation expressed gene 2 protein (sST2) levels in patients with heart failure, with and without obesity/overweight.
methodsSerum samples were collected from patients with heart failure admitted to the Second Xiangya Hospital, Central South University, between October 2023 and March 2024. Participants were divided into three groups: heart failure with obesity/overweight group (
resultsSerum levels of sST2, N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), and blood glucose (GLU) were significantly higher in patients with heart failure than in healthy controls, whereas total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were significantly lower (all
conclusionssST2 has substantial diagnostic value in patients with heart failure without overweight or obesity, but limited value in patients with overweight or obesity. Combined assessment of sST2, age, BMI, and HDL-C significantly enhances its diagnostic utility for heart failure. This model may be applicable for rapid heart failure screening in primary healthcare settings; however, prospective studies are required for further validation.
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